Targeted inhibition of G q signaling induces airway relaxation in mouse models of asthma-Reference-Cited by-同舟云学术

Targeted inhibition of G q signaling induces airway relaxation in mouse models of asthma

Published:2017-09-13 Issue:407 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Matthey Michaela¹^ORCID,Roberts Richard²,Seidinger Alexander¹,Simon Annika¹,Schröder Ralf³,Kuschak Markus⁴^ORCID,Annala Suvi³^ORCID,König Gabriele M.⁵⁶,Müller Christa E.⁴⁶,Hall Ian P.⁷^ORCID,Kostenis Evi³⁶^ORCID,Fleischmann Bernd K.¹⁶^ORCID,Wenzel Daniela¹^ORCID

Affiliation:

1. Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.

2. Pharmacology Research Group, University Hospital of Nottingham, Nottingham, UK.

3. Molecular, Cellular, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.

4. Pharmaceutical Institute, Institute of Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany.

5. Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.

6. PharmaCenter, University of Bonn, Bonn, Germany.

7. Division of Respiratory Medicine, University Hospital of Nottingham, Nottingham, UK.

Abstract

Local pharmacological inhibition of G q results in airway relaxation in mouse models of asthma.

Funder

DFG

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference34 articles.

1. Regulation of Heterotrimeric G Protein Signaling in Airway Smooth Muscle

2. Increased expression of G.ALPHA.q protein in bronchial smooth muscle of mice with allergic bronchial asthma

3. Alteration of G protein levels in antigen-challenged guinea pigs;Lee J. Y.;J. Pharmacol. Exp. Ther.,1994

4. Combination Therapy for Chronic Obstructive Pulmonary Disease: Clinical Aspects

Cited by 54 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Stabilization of interdomain closure by a G protein inhibitor;Proceedings of the National Academy of Sciences;2024-08-28

2. Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension;EMBO Molecular Medicine;2024-07-08

3. Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy;Chemical Science;2024

4. Recommended Tool Compounds: Application of YM-254890 and FR900359 to Interrogate Gα_q/11-Mediated Signaling Pathways;ACS Pharmacology & Translational Science;2023-11-10

5. Cyclic peptide inhibitors stabilize Gq/11 heterotrimers;2023-10-24