Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment

Author:

Zemek Rachael M.12ORCID,De Jong Emma3ORCID,Chin Wee Loong245,Schuster Iona S.678,Fear Vanessa S.24,Casey Thomas H.12ORCID,Forbes Cath24,Dart Sarah J.12ORCID,Leslie Connull9,Zaitouny Ayham1011,Small Michael1011,Boon Louis12ORCID,Forrest Alistair R. R.13ORCID,Muiri Daithi O.13,Degli-Esposti Mariapia A.678ORCID,Millward Michael J.45,Nowak Anna K.245ORCID,Lassmann Timo3ORCID,Bosco Anthony3ORCID,Lake Richard A.12ORCID,Lesterhuis W. Joost123ORCID

Affiliation:

1. School of Biomedical Sciences, University of Western Australia, M503, Crawley, WA 6009, Australia.

2. National Centre for Asbestos Related Diseases, 5th Floor QQ Block, 6 Verdun Street, Nedlands, WA 6009, Australia.

3. Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, WA 6872, Australia.

4. Medical School, University of Western Australia, M503, Crawley, WA 6009, Australia.

5. Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Ave, Nedlands, WA 6009, Australia.

6. Immunology and Virology Program, Centre for Ophthalmology and Visual Science, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.

7. Centre for Experimental Immunology, Lions Eye Institute, 2 Verdun Street, Nedlands, WA 6009, Australia.

8. Infection and Immunity Program and Department of Microbiology, Biomedicine Discovery Institute, Monash University, VIC 3800, Australia.

9. Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA 6009, Australia.

10. School of Mathematics and Statistics, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.

11. CSIRO, Mineral Resources, 26 Dick Perry Ave, Kensington, WA, 6152, Australia.

12. Bioceros, Yalelaan 46, Alexander Numan Building, 3584 CM Utrecht, Netherlands.

13. Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, University of Western Australia, 6 Verdun Street, Nedlands, WA 6009, Australia.

Abstract

A STAT1-driven inflammatory phenotype associated with response to checkpoint blocking antibodies sensitizes cancers to immunotherapy.

Funder

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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