The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans-Reference-Cited by-同舟云学术

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

Published:2019-04-24 Issue:489 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tirosh Amir¹²³⁴^ORCID,Calay Ediz S.³^ORCID,Tuncman Gurol³^ORCID,Claiborn Kathryn C.³,Inouye Karen E.³^ORCID,Eguchi Kosei³,Alcala Michael³^ORCID,Rathaus Moran¹,Hollander Kenneth S.¹²^ORCID,Ron Idit¹,Livne Rinat¹,Heianza Yoriko⁵,Qi Lu⁵,Shai Iris⁶,Garg Rajesh⁴⁷^ORCID,Hotamisligil Gökhan S.³⁸^ORCID

Affiliation:

1. Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.

2. Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

3. Department of Genetics and Complex Diseases & Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

4. Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

5. Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

6. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

7. Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, 5555 Ponce de Leon Boulevard, Coral Gables, FL, USA.

8. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Abstract

Propionate activates the insulin counter-regulatory hormonal response in mice, resulting in insulin resistance and weight gain.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Nutrition Obesity Research Center at Harvard

Israeli Ministry of Health

Cardiovascular, Diabetes and Metabolic Disorder Research Center of the Brigham Research Institute

Genes and the Environment Training Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. I. D. Federation IDF Diabetes Atlas (International Diabetes Federation Brussels Belgium ed. 7 2015).

2. Diabetes: Have We Got It All Wrong?: Insulin hypersecretion and food additives: cause of obesity and diabetes?

3. Subpart B-Listing of Specific Substances Affirmed as GRAS. Sec. 184.1081 Propionic acid. (2012).

4. Regulation of short-chain fatty acid production

5. THE CHEMISTRY OF GLUCONEOGENESIS

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