Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates-Reference-Cited by-同舟云学术

Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates

Published:2019-05-22 Issue:493 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Milani Michela¹²^ORCID,Annoni Andrea¹^ORCID,Moalli Federica³,Liu Tongyao⁴,Cesana Daniela¹^ORCID,Calabria Andrea¹^ORCID,Bartolaccini Sara¹,Biffi Mauro¹,Russo Fabio¹,Visigalli Ilaria¹,Raimondi Andrea³^ORCID,Patarroyo-White Susannah⁴,Drager Douglas⁴,Cristofori Patrizia¹⁵^ORCID,Ayuso Eduard⁶^ORCID,Montini Eugenio¹,Peters Robert⁴^ORCID,Iannacone Matteo³^ORCID,Cantore Alessio¹²^ORCID,Naldini Luigi¹²^ORCID

Affiliation:

1. San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

2. Vita-Salute San Raffaele University, 20132 Milan, Italy.

3. IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.

4. Bioverativ, Waltham, MA 02451, USA.

5. GlaxoSmithKline R&D UK, Ware SG12 0DP, UK.

6. INSERM UMR1089, University of Nantes, CHU de Nantes, 44093 Nantes, France.

Abstract

Lentiviral vectors with high surface content of CD47 improved gene transfer efficiency to hepatocytes in nonhuman primates.

Funder

Fondazione Telethon

Bioverativ