Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis-Reference-Cited by-同舟云学术

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

Published:2019-04-03 Issue:486 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Esther Charles R.¹²^ORCID,Muhlebach Marianne S.¹²^ORCID,Ehre Camille¹²^ORCID,Hill David B.²³,Wolfgang Matthew C.²,Kesimer Mehmet²,Ramsey Kathryn A.²⁴^ORCID,Markovetz Matthew R.²^ORCID,Garbarine Ian C.²,Forest M. Gregory⁵,Seim Ian⁵^ORCID,Zorn Bryan²,Morrison Cameron B.²^ORCID,Delion Martial F.²,Thelin William R.⁶^ORCID,Villalon Diane⁶,Sabater Juan R.⁷,Turkovic Lidija⁴,Ranganathan Sarath⁸,Stick Stephen M.⁴⁹¹⁰^ORCID,Boucher Richard C.²

Affiliation:

1. Division of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. Telethon Kids Institute, University of Western Australia, Perth 6009, Australia.

5. Departments of Mathematics, Biomedical Engineering, and Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Parion Sciences, Durham, NC 27713, USA.

7. Department of Research, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.

8. Murdoch Children’s Research Institute, University of Melbourne, Parkville 3052, Australia.

9. Division of Paediatrics and Child Health, University of Western Australia, Perth 6009, Australia.

10. Princess Margaret Hospital for Children, Perth 6009, Australia.

Abstract

Increased airway mucus, occurs before infection or structural lung disease in early cystic fibrosis and promotes inflammation.

Funder

National Science Foundation

National Heart, Lung, and Blood Institute

National Institute of Environmental Health Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Cystic Fibrosis Foundation

National Health and Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference72 articles.

1. Cystic Fibrosis Since 1938

2. Progression of early structural lung disease in young children with cystic fibrosis assessed using CT

3. Lung Disease at Diagnosis in Infants with Cystic Fibrosis Detected by Newborn Screening

4. Cystic fibrosis: An inherited disease affecting mucin-producing organs

5. PANCREATIC FUNCTION AND DISEASE IN EARLY LIFE. I. PANCREATIC ENZYME ACTIVITY AND THE CELIAC SYNDROME 1

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