Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease-Reference-Cited by-同舟云学术

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

Published:2019-08-14 Issue:505 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tian Jing¹^ORCID,Guo Lan¹,Sui Shaomei¹²,Driskill Christopher³,Phensy Aarron³^ORCID,Wang Qi¹²,Gauba Esha¹,Zigman Jeffrey M.⁴^ORCID,Swerdlow Russell H.⁵,Kroener Sven³^ORCID,Du Heng¹^ORCID

Affiliation:

1. Department of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

2. Department of Neurology, Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong 250014, China.

3. School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

4. Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

5. Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Abstract

GHSR1α and DRD1 coactivation preserves the integrity of hippocampal synapses in Alzheimer’s disease.

Funder

National Institutes of Health

China Scholarship Council

Alzheimer’s Association

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference72 articles.

1. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

2. Update on Alzheimer's Disease Therapy and Prevention Strategies

3. Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse

4. Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways

5. The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

Cited by 47 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta;Journal of Neuroinflammation;2024-08-11

2. Immunopathogenesis of Alzheimer’s disease, Parkinson’s Disease, and other Neurodegenerative Diseases;Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases;2024-07-28

3. Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review;Antioxidants;2024-05-27

4. Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases;Signal Transduction and Targeted Therapy;2024-02-16

5. Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging;Journal of Alzheimer's Disease;2023-12-06