Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

Author:

Hill James M.1,Quenelle Debra C.2,Cardin Rhonda D.3,Vogel Jodi L.4,Clement Christian1,Bravo Fernando J.3,Foster Timothy P.1,Bosch-Marce Marta5,Raja Priya6,Lee Jennifer S.67,Bernstein David I.3,Krause Philip R.5,Knipe David M.67,Kristie Thomas M.4

Affiliation:

1. Department of Ophthalmology and Department of Microbiology, Immunology, and Parasitology, LSU Eye Center, Louisiana State University Health Science Center School of Medicine, New Orleans, LA 70112, USA.

2. Department of Pediatric Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

3. Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

4. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20852, USA.

6. Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA.

7. Harvard Program in Virology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Epigenetic suppression of herpes simplex virus demonstrates an approach to control persistent viruses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference63 articles.

1. Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update

2. The High Prevalence of Herpes Simplex Virus Type 1 DNA in Human Trigeminal Ganglia Is Not a Function of Age or Gender

3. R. Whitley D. W. Kimberlin C. G. Prober in Human Herpesviruses Biology Therapy and Immunoprophylaxis A. Arvin R. Whitley Eds. (Cambridge Univ. Press Cambridge 2007) chap. 32 pp. 589–601.

4. B. Roizman D. M. Knipe R. J. Whitley in Fields Virology D. M. Knipe P. M. Howley Eds. (Lippincott Williams & Wilkins Philadelphia ed. 6 2013).

5. Herpes simplex keratitis

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