Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients-Reference-Cited by-同舟云学术

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

Published:2017-10-25 Issue:413 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Michelakis Evangelos D.¹^ORCID,Gurtu Vikram¹,Webster Linda¹,Barnes Gareth²,Watson Geoffrey²^ORCID,Howard Luke³^ORCID,Cupitt John²,Paterson Ian¹,Thompson Richard B.⁴,Chow Kelvin⁴,O’Regan Declan P.⁵^ORCID,Zhao Lan²^ORCID,Wharton John²^ORCID,Kiely David G.⁶^ORCID,Kinnaird Adam¹,Boukouris Aristeidis E.¹^ORCID,White Chris⁷^ORCID,Nagendran Jayan⁷^ORCID,Freed Darren H.⁷^ORCID,Wort Stephen J.⁸,Gibbs J. Simon R.³,Wilkins Martin R.²^ORCID

Affiliation:

1. Department of Medicine, University of Alberta, Edmonton, Alberta T6G2B7, Canada.

2. Department of Medicine, Imperial College London, London W12 0NN, UK.

3. National Pulmonary Hypertension Service, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

4. Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta T6G2B7, Canada.

5. Medical Research Council, London Institute of Medical Sciences, Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK.

6. Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield S10 2JF, UK.

7. Department of Surgery, University of Alberta, Edmonton, Alberta T6G2B7, Canada.

8. National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.

Abstract

Metabolic modulation with dichloroacetate improves hemodynamics in genetically susceptible patients with idiopathic pulmonary arterial hypertension.

Funder

Canadian Institutes of Health Research, the Heart and Stroke Foundation of Canada

The National Institute for Health Research (NIHR)/Wellcome Trust

Medical Research Council and British Heart Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

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3. Mitochondria in Vascular Health and Disease

4. The Metabolic Theory of Pulmonary Arterial Hypertension

5. The Metabolic Basis of Pulmonary Arterial Hypertension

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