Production and transplantation of bioengineered lung into a large-animal model

Author:

Nichols Joan E.1ORCID,La Francesca Saverio2ORCID,Niles Jean A.1ORCID,Vega Stephanie P.3ORCID,Argueta Lissenya B.4,Frank Luba5,Christiani David C.67,Pyles Richard B.8ORCID,Himes Blanca E.9ORCID,Zhang Ruyang7,Li Su7ORCID,Sakamoto Jason10ORCID,Rhudy Jessica10ORCID,Hendricks Greg11ORCID,Begarani Filippo10,Liu Xuewu10ORCID,Patrikeev Igor12,Pal Rahul12,Usheva Emiliya13ORCID,Vargas Grace12,Miller Aaron8,Woodson Lee14ORCID,Wacher Adam14,Grimaldo Maria1,Weaver Daniil1ORCID,Mlcak Ron15,Cortiella Joaquin14ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.

2. Biostage Inc., Holliston, MA 01746, USA.

3. Department of Microbiology and Immunology, UTMB, Galveston, TX 77555, USA.

4. Weill Cornell Medical College, New York, NY 10065, USA.

5. Department of Radiology, UTMB, Galveston, TX 77555, USA.

6. Pulmonary Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

7. Environmental, Occupational Medicine, Epidemiology Department, TH Chan School of Public Health, Harvard University, Boston, MA 02115, USA.

8. Galveston National Laboratory, Assay Development Core, UTMB, Galveston, TX 77555, USA.

9. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

10. Houston Methodist Hospital Research Institute, Houston, TX 77030, USA.

11. Radiology Division of Cell Biology, University of Massachusetts Medical School, Worchester, MA 01605, USA.

12. Center for Biomedical Engineering, UTMB, Galveston, TX 77555, USA.

13. University of Texas Southwestern Medical School, Dallas, TX 75390, USA.

14. Department of Anesthesiology, UTMB, Galveston, TX 77555, USA.

15. Shriners Hospital for Children, Galveston, TX 77550, USA.

Abstract

Nanoparticle delivery of growth factors promotes capillary development in bioengineered lungs during bioreactor culture and transplantation in a pig model.

Funder

NIH NCATS

Pilot Grant from James Leduc Ph.D. at Univesity of Texas Medical Branch, Galveston

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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