Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice-Reference-Cited by-同舟云学术

Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice

Published:2021-11-24 Issue:621 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Manigrasso Michaele B.¹^ORCID,Rabbani Piul²^ORCID,Egaña-Gorroño Lander¹^ORCID,Quadri Nosirudeen¹^ORCID,Frye Laura¹,Zhou Boyan³^ORCID,Reverdatto Sergey⁴^ORCID,Ramirez Lisa S.⁴^ORCID,Dansereau Stephen⁴,Pan Jinhong⁴,Li Huilin³^ORCID,D’Agati Vivette D.⁵,Ramasamy Ravichandran¹^ORCID,DeVita Robert J.⁶,Shekhtman Alexander⁴^ORCID,Schmidt Ann Marie¹^ORCID

Affiliation:

1. Diabetes Research Program, Division of Endocrinology, Diabetes and Metabolism, NYU Langone Health, New York, NY 10016, USA.

2. Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY 10016, USA.

3. Departments of Population Health (Biostatistics) and Environmental Medicine, NYU Langone Health, New York, NY 10016, USA.

4. Department of Chemistry, State University of New York at Albany, Albany, NY 12222, USA.

5. Department of Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA.

6. RJD Medicinal Chemistry and Drug Discovery Consulting LLC, Westfield, NJ 07091, USA.

Abstract

Small-molecule antagonism of RAGE-DIAPH1 reduces diabetes-related complications in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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