The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates-Reference-Cited by-同舟云学术

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

Published:2021-05-12 Issue:593 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Jones Bryan E.¹^ORCID,Brown-Augsburger Patricia L.²^ORCID,Corbett Kizzmekia S.³^ORCID,Westendorf Kathryn⁴^ORCID,Davies Julian¹^ORCID,Cujec Thomas P.¹^ORCID,Wiethoff Christopher M.²^ORCID,Blackbourne Jamie L.²^ORCID,Heinz Beverly A.²,Foster Denisa¹,Higgs Richard E.²^ORCID,Balasubramaniam Deepa¹^ORCID,Wang Lingshu³,Zhang Yi³^ORCID,Yang Eun Sung³^ORCID,Bidshahri Roza⁴^ORCID,Kraft Lucas⁴,Hwang Yuri⁴^ORCID,Žentelis Stefanie⁴,Jepson Kevin R.⁴^ORCID,Goya Rodrigo⁴,Smith Maia A.⁴,Collins David W.⁴^ORCID,Hinshaw Samuel J.⁴^ORCID,Tycho Sean A.⁴,Pellacani Davide⁴,Xiang Ping⁴^ORCID,Muthuraman Krithika⁴,Sobhanifar Solmaz⁴,Piper Marissa H.¹,Triana Franz J.¹,Hendle Jorg¹^ORCID,Pustilnik Anna¹^ORCID,Adams Andrew C.²,Berens Shawn J.²,Baric Ralph S.⁵^ORCID,Martinez David R.⁵,Cross Robert W.⁶^ORCID,Geisbert Thomas W.⁶^ORCID,Borisevich Viktoriya⁶,Abiona Olubukola³^ORCID,Belli Hayley M.⁷^ORCID,de Vries Maren⁸^ORCID,Mohamed Adil⁸^ORCID,Dittmann Meike⁸^ORCID,Samanovic Marie I.⁹^ORCID,Mulligan Mark J.⁹,Goldsmith Jory A.¹⁰,Hsieh Ching-Lin¹⁰^ORCID,Johnson Nicole V.¹⁰^ORCID,Wrapp Daniel¹⁰^ORCID,McLellan Jason S.¹⁰^ORCID,Barnhart Bryan C.⁴^ORCID,Graham Barney S.³^ORCID,Mascola John R.³^ORCID,Hansen Carl L.⁴,Falconer Ester⁴^ORCID

Affiliation:

1. Lilly Biotechnology Center, Eli Lilly and Company, San Diego, CA 92121, USA.

2. Eli Lilly and Company, Indianapolis, IN 46225, USA.

3. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

4. AbCellera Biologics Inc., Vancouver, BC V5Y0A1, Canada.

5. University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Galveston National Laboratory and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

7. Department of Population Health, Division of Biostatistics, New York University Grossman School of Medicine, New York, NY 10016, USA.

8. Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.

9. NYU Langone Vaccine Center, Department of Medicine, Division of Infectious Diseases and Immunology, New York University Grossman School of Medicine, New York, NY 10016, USA.

10. Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

Abstract

LY-CoV555, a SARS-CoV-2 spike protein–specific antibody, neutralizes SARS-CoV-2 and protects the airways of nonhuman primates against infection.

Funder

National Institutes of Health

U.S. Department of Energy

Eli Lilly and Company

Defense Sciences Office, DARPA

The G. Harold and Leila Y. Mathers Charitable Foundation

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)