Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function

Author:

Ali Aadil1ORCID,Wang Aizhou1,Ribeiro Rafaela V. P.1ORCID,Beroncal Erika L.2,Baciu Cristina1ORCID,Galasso Marcos1,Gomes Bruno1,Mariscal Andrea1ORCID,Hough Olivia1,Brambate Edson1,Abdelnour-Berchtold Etienne1ORCID,Michaelsen Vinicius1ORCID,Zhang Yu1,Gazzalle Anajara1,Fan Eddy3,Brochard Laurent34,Yeung Jonathan15,Waddell Tom15ORCID,Liu Mingyao1ORCID,Andreazza Ana C.2ORCID,Keshavjee Shaf15,Cypel Marcelo15ORCID

Affiliation:

1. Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada.

2. Departments of Pharmacology & Toxicology and Psychiatry, The Canada Mitochondrial Network, University of Toronto, Toronto, ON M5S 1A8, Canada.

3. Divisions of Respirology and Critical Care Medicine, University Health Network, University of Toronto, Toronto, ON M5B 1W8, Canada.

4. Keenan Research Centre, St Michael’s Hospital, Unity Health Toronto and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, M5B 1T8, Canada.

5. Division of Thoracic Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto Lung Transplant Program, Toronto, ON M5G 2C4, Canada.

Abstract

Static storage of donor lungs at 10°C enhances mitochondrial protection and is a clinically feasible option to extend viable lung preservation times.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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