Aberrant activation of m6A demethylase FTO renders HIF2α low/− clear cell renal cell carcinoma sensitive to BRD9 inhibitors-Reference-Cited by-同舟云学术

Aberrant activation of m6A demethylase FTO renders HIF2α low/− clear cell renal cell carcinoma sensitive to BRD9 inhibitors

Published:2021-09-29 Issue:613 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang ChuanJie¹²^ORCID,Chen Lu¹^ORCID,Lou WeiJuan²^ORCID,Su JunHui²,Huang JingYi¹,Liu Ao¹,Xu Yang¹,He HongChao¹,Gao Yi¹,Xu DanFeng¹^ORCID,Li QingQuan²^ORCID

Affiliation:

1. Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.

Abstract

Activation of the FTO-BRD9 axis confers growth advantage and vulnerability to BRD9 inhibitors in HIF2α low/− clear cell renal cell carcinoma.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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