Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

Author:

Lin Yao-Xin1ORCID,Wang Yi123ORCID,Ding Jianxun1ORCID,Jiang Aiping4,Wang Jie23,Yu Mian5ORCID,Blake Sara16ORCID,Liu Shuaishuai7,Bieberich Charles J.78ORCID,Farokhzad Omid C.1ORCID,Mei Lin59ORCID,Wang Hao23ORCID,Shi Jinjun1ORCID

Affiliation:

1. Center for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. CAS Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China.

3. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

4. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

5. School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Guangzhou, Guangdong 510006, China.

6. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

7. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250 USA.

8. University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.

9. Tianjin Key Laboratory of Biomedical Materials and Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.

Abstract

The restoration of tumor suppressor PTEN by synthetic mRNA nanoparticles sensitizes Pten -null or mutated tumors to immune checkpoint blockade therapy.

Funder

National Institutes of Health

Harvard Medical School Neurobiology Imaging Facility

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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