Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings-Reference-Cited by-同舟云学术

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings

Published:2020-11-18 Issue:570 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lomoio Selene¹^ORCID,Willen Rachel¹,Kim WonHee¹^ORCID,Ho Kevin Z.¹,Robinson Edward K.¹,Prokopenko Dmitry²^ORCID,Kennedy Matthew E.³^ORCID,Tanzi Rudolph E.²^ORCID,Tesco Giuseppina¹^ORCID

Affiliation:

1. Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.

2. Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

3. Department of Neuroscience, Merck & Co. Inc., Boston, MA 02115, USA.

Abstract

GGA3-mediated BACE1 accumulation in dystrophic neurites is an early pathogenic event and is independent of Aβ extracellular deposition.

Funder

National Institute on Aging

BrightFocus Foundation

Cure Alzheimer’s Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference64 articles.