T follicular helper–like cells contribute to skin fibrosis-Reference-Cited by-同舟云学术

T follicular helper–like cells contribute to skin fibrosis

Published:2018-03-07 Issue:431 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Taylor Devon K.¹^ORCID,Mittereder Nanette¹,Kuta Ellen¹,Delaney Tracy¹,Burwell Timothy¹,Dacosta Karma²^ORCID,Zhao Weiguang²,Cheng Lily I.²^ORCID,Brown Charles²,Boutrin Anmarie²^ORCID,Guo Xiang³^ORCID,White Wendy I.³,Zhu Jie⁴,Dong Huifang⁴^ORCID,Bowen Michael A.⁴,Lin Jia⁴,Gao Changshou⁴^ORCID,Yu Li⁵^ORCID,Ramaswamy Madhu¹^ORCID,Gaudreau Marie-Claude¹^ORCID,Woods Rob⁴,Herbst Ronald¹,Carlesso Gianluca¹^ORCID

Affiliation:

1. Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD 20878, USA.

2. Department of Pathology, MedImmune LLC, Gaithersburg, MD 20878, USA.

3. Department of Clinical Biomarkers and Computational Biology, MedImmune LLC, Gaithersburg, MD 20878, USA.

4. Department of Antibody Discovery and Protein Engineering, MedImmune LLC, Gaithersburg, MD 20878, USA.

5. Clinical Pharmacology, Pharmacometrics, and DMPK (CPD), MedImmune LLC, Gaithersburg, MD 20878, USA.

Abstract

T follicular helper–like cells and IL-21 are drivers of skin fibrosis in systemic sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference64 articles.

1. Scleroderma

2. Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

3. Fibrotic disease and the TH1/TH2 paradigm

4. Lymphocytes in the skin of patients with progressive systemic sclerosis

5. Early T cell activation in the skin from patients with systemic sclerosis

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