MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration-Reference-Cited by-同舟云学术

MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration

Published:2021-11-03 Issue:618 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Barker Scarlett J.¹²^ORCID,Raju Ravikiran M.¹³^ORCID,Milman Noah E.P.¹^ORCID,Wang Jun¹,Davila-Velderrain Jose⁴^ORCID,Gunter-Rahman Fatima¹^ORCID,Parro Cameron C.¹,Bozzelli P. Lorenzo¹^ORCID,Abdurrob Fatema¹^ORCID,Abdelaal Karim¹^ORCID,Bennett David A.⁵^ORCID,Kellis Manolis⁴⁶^ORCID,Tsai Li-Huei¹²⁶^ORCID

Affiliation:

1. Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

5. Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.

6. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Abstract

Mef2 is induced after enrichment in mice, reduces disease-associated hyperexcitability, and is a feature of cognitive resilience in patients with AD.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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