Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy-Reference-Cited by-同舟云学术

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

Published:2015-02-25 Issue:276 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kau Andrew L.¹²,Planer Joseph D.¹,Liu Jie³,Rao Sindhuja²,Yatsunenko Tanya¹,Trehan Indi⁴⁵,Manary Mark J.⁴⁶,Liu Ta-Chiang⁷,Stappenbeck Thaddeus S.⁷,Maleta Kenneth M.⁶,Ashorn Per⁸,Dewey Kathryn G.⁹,Houpt Eric R.³,Hsieh Chyi-Song²,Gordon Jeffrey I.¹

Affiliation:

1. Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

2. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

4. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Paediatrics and Child Health, College of Medicine, University of Malawi, Chichiri, Blantyre 3, Malawi.

6. Department of Community Health, College of Medicine, University of Malawi, Chichiri, Blantyre 3, Malawi.

7. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

8. Department for International Health, University of Tampere School of Medicine, Tampere 33014, Finland.

9. Department of Nutrition, and Program in International and Community Nutrition, University of California, Davis, Davis, CA 95616, USA.

Abstract

Gut bacterial strains targeted by IgA in undernourished Malawian children produce severe enteropathy in gnotobiotic mice and correlate with health status.

Funder

NIH

Bill & Melinda Gates Foundation

NIH Ruth L. Kirschstein National Research Service Award

Washington University Medical Scientist Training Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

1. World Health Organization Levels and Trends in Child Malnutrition UNICEF-WHO-The World Bank Joint Child Malnutrition Estimates (2012)

2. http://who.int/nutgrowthdb/estimates/en/ (2012).