An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease-Reference-Cited by-同舟云学术

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

Published:2015-08-12 Issue:300 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Sufeng¹²³,Ermann Joerg⁴⁵,Succi Marc D.¹²⁵,Zhou Allen²,Hamilton Matthew J.⁵⁶,Cao Bonnie⁶,Korzenik Joshua R.⁵⁶,Glickman Jonathan N.⁵⁷,Vemula Praveen K.⁸,Glimcher Laurie H.⁹,Traverso Giovanni¹⁵¹⁰,Langer Robert¹³¹¹,Karp Jeffrey M.²⁵¹¹¹²

Affiliation:

1. The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Center for Regenerative Therapeutics, Biomedical Research Institute, Brigham and Women’s Hospital, Boston, MA 02115, USA.

3. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA 02115, USA.

5. Harvard Medical School, Boston, MA 02115, USA.

6. Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Boston, MA 02115, USA.

7. Miraca Life Sciences, Newton, MA 02464, USA.

8. Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore 560065, India.

9. Weill Cornell Medical College, New York, NY 10065, USA.

10. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.

11. Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

12. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Abstract

A hydrogel binds to inflamed tissues, delivering therapeutics locally and reducing systemic drug exposure in mouse models of inflammatory bowel disease.

Funder

NIH

Alexander von Humboldt Foundation

Harvard Institute of Translational Immunology/Helmsley Trust Pilot

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference41 articles.

1. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences

2. Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

4. Impact of inflammatory bowel disease on quality of life: Results of the European Federation of Crohn’s and Ulcerative Colitis Associations (EFCCA) patient survey

5. Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

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