Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis-Reference-Cited by-同舟云学术

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

Published:2015-05-13 Issue:287 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cao Yonghao¹,Goods Brittany A.²,Raddassi Khadir¹,Nepom Gerald T.³,Kwok William W.³⁴,Love J. Christopher⁵⁶,Hafler David A.¹⁶

Affiliation:

1. Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.

2. Department of Biological Engineering, Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

3. Benaroya Research Institute, Virginia Mason Research Center, Seattle, WA 98101, USA.

4. Department of Medicine, University of Washington, Seattle, WA 98101, USA.

5. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

6. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Abstract

CCR6 + myelin-reactive T cells from patients with multiple sclerosis secrete inflammatory cytokines compared to T cells from healthy subjects, showing a distinct pathogenic gene expression profile and sharing a transcriptome homology with encephalitogenic CD4 + T cells isolated from mice with experimental autoimmune encephalitis.

Funder

NIH

National Institute of Neurological Disorders and Stroke

Nancy Taylor Foundation for Chronic Diseases Inc.

Koch Institute Support

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. Multiple sclerosis: a complicated picture of autoimmunity

2. Autoimmune T cell responses in the central nervous system