Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia-Reference-Cited by-同舟云学术

Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia

Published:2015-04 Issue:281 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Paguirigan Amy L.¹,Smith Jordan¹,Meshinchi Soheil¹,Carroll Martin²,Maley Carlo³⁴,Radich Jerald P.¹

Affiliation:

1. Fred Hutchinson Cancer Research Center, Seattle, WA 98117, USA.

2. University of Pennsylvania, Philadelphia, PA, 19104, USA.

3. Center for Evolution and Cancer, Helen Diller Family Comprehensive Cancer Center and Department of Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.

4. School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.

Abstract

The targeted genotyping of single acute myeloid leukemia cells is technically feasible, identifies the zygosities of concurrent mutations, and suggests that sequencing of bulk populations may underestimate clonal complexity.

Funder

NIH

American Cancer Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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