Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model-Reference-Cited by-同舟云学术

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

Published:2015-05-20 Issue:288 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

van den Driesche Sander¹,Macdonald Joni¹,Anderson Richard A.¹,Johnston Zoe C.¹,Chetty Tarini²,Smith Lee B.¹,McKinnell Chris¹,Dean Afshan¹,Homer Natalie Z.³,Jorgensen Anne¹⁴,Camacho-Moll Maria E.¹,Sharpe Richard M.¹,Mitchell Rod T.¹²

Affiliation:

1. MRC Centre for Reproductive Health, The University of Edinburgh, The Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK.

2. Edinburgh Royal Hospital for Sick Children, 9 Sciennes Road, Edinburgh EH9 1LF, Scotland, UK.

3. Edinburgh CRF Mass Spectrometry Core, Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK.

4. University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Abstract

Prolonged exposure to therapeutic doses of acetaminophen reduces testosterone production by human fetal testis xenografts in mice.

Funder

Wellcome Trust Intermediate Clinical Fellowship

UK Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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