Immune-mediated pathology in Duchenne muscular dystrophy

Author:

Rosenberg Amy S.1,Puig Montserrat1,Nagaraju Kanneboyina2,Hoffman Eric P.2,Villalta S. Armando3,Rao V. Ashutosh1,Wakefield Lalage M.4,Woodcock Janet1

Affiliation:

1. Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 71/2238, Silver Spring, MD 20993, USA.

2. Center for Genetic Medicine Research, Children’s National Medical Center, Washington, DC 20010, USA.

3. Department of Physiology and Biophysics, Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA.

4. Laboratory of Cancer Biology and Genetics, National Cancer Institute, Building 37, Room 4032A, Bethesda, MD 20892, USA.

Abstract

Immunopathology contributes to the destruction and fibrosis of muscle in Duchenne muscular dystrophy, reducing the efficacy of dystrophin-replacement therapies.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference109 articles.

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