Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients

Author:

Schonhoft Joseph D.12ORCID,Monteiro Cecilia12ORCID,Plate Lars12ORCID,Eisele Yvonne S.12ORCID,Kelly John M.2ORCID,Boland Daniel1ORCID,Parker Christopher G.123,Cravatt Benjamin F.123ORCID,Teruya Sergio4ORCID,Helmke Stephen4ORCID,Maurer Mathew4ORCID,Berk John5ORCID,Sekijima Yoshiki6ORCID,Novais Marta7ORCID,Coelho Teresa7ORCID,Powers Evan T.1ORCID,Kelly Jeffery W.123

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

4. Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

5. Boston University School of Medicine, Boston, MA 02118, USA.

6. Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

7. Unidade Corino de Andrade, Department of Neurosciences, Hospital de Santo António, 4099-001 Porto, Portugal.

Abstract

Peptide probes detect misfolded transthyretin oligomers in amyloidosis patient plasma.

Funder

National Institutes of Health

American Heart Association

Damon Runyon Cancer Research Foundation

Leukemia and Lymphoma Society

DAAD

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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