A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage-Reference-Cited by-同舟云学术

A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage

Published:2021-07-07 Issue:601 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Laver Jay R.¹²^ORCID,Gbesemete Diane¹²,Dale Adam P.¹²^ORCID,Pounce Zoe C.¹,Webb Carl N.¹²^ORCID,Roche Eleanor F.¹,Guy Jonathan M.¹,Berreen Graham¹,Belogiannis Konstantinos¹^ORCID,Hill Alison R.¹²^ORCID,Ibrahim Muktar M.¹^ORCID,Ahmed Muhammad¹^ORCID,Cleary David W.¹²^ORCID,Pandey Anish K.¹²^ORCID,Humphries Holly E.³^ORCID,Allen Lauren³^ORCID,de Graaf Hans¹²^ORCID,Maiden Martin C.⁴^ORCID,Faust Saul N.¹²^ORCID,Gorringe Andrew R.³^ORCID,Read Robert C.¹²^ORCID

Affiliation:

1. Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.

2. NIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.

3. Public Health England, Porton Down, Salisbury SP4 0JG, UK.

4. Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK.

Abstract

An engineered commensal bacteria with a surface-expressed vaccine target provoked antigen-specific antibodies during pharyngeal carriage in humans.

Funder

Wellcome

Medical Research Council

National Institute for Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine