Antioxidants Accelerate Lung Cancer Progression in Mice-Reference-Cited by-同舟云学术

Antioxidants Accelerate Lung Cancer Progression in Mice

Published:2014-01-29 Issue:221 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sayin Volkan I.¹²³,Ibrahim Mohamed X.¹,Larsson Erik³,Nilsson Jonas A.¹⁴,Lindahl Per²³,Bergo Martin O.¹

Affiliation:

1. Sahlgrenska Cancer Center, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

2. Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden.

3. Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

4. Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.

Abstract

The antioxidants acetylcysteine and vitamin E accelerate tumor progression and reduce survival in mouse models of lung cancer by disrupting the ROS-p53 axis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference41 articles.

1. Antioxidants and Prevention of Chronic Disease

2. Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

3. The antioxidant function of the p53 tumor suppressor

4. c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

5. Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population

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