Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Author:

Wenger Nikolaus1,Moraud Eduardo Martin23,Raspopovic Stanisa24,Bonizzato Marco2,DiGiovanna Jack2,Musienko Pavel15,Morari Manfred3,Micera Silvestro24,Courtine Grégoire1

Affiliation:

1. International Paraplegic Foundation Chair in Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne CH-1015, Switzerland.

2. Translational Neural Engineering Lab, Center for Neuroprosthetics and Institute of Bioengineering, School of Bioengineering, Swiss Federal Institute of Technology (EPFL), Lausanne CH-1015, Switzerland.

3. Automatic Control Laboratory, Swiss Federal Institute of Technology (ETHZ), Zurich CH-8092, Switzerland.

4. The BioRobotics Institute, Scuola Superiore Sant’Anna, Pisa IT-56025, Italy.

5. Pavlov Institute of Physiology, St. Petersburg RU-100034, Russia.

Abstract

Closed-loop neuromodulation of spinal sensorimotor circuits allows high-fidelity control over leg movements in paralyzed rats.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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