Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design

Author:

Wei Chih-Jen1,Boyington Jeffrey C.1,Dai Kaifan1,Houser Katherine V.2,Pearce Melissa B.2,Kong Wing-Pui1,Yang Zhi-yong1,Tumpey Terrence M.2,Nabel Gary J.1

Affiliation:

1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892–3005, USA.

2. Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

Abstract

The 1918 and 2009 pandemic influenza viruses are both inhibited by antibodies directed to an exposed region of the viral spike, but this region becomes shielded by glycans in influenza seasonal strains.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference30 articles.

1. World Health Organization DG Statement following the meeting of the Emergency Committee (World Health Organization Geneva 2009); http://www.who.int/csr/disease/swineflu/4th_meeting_ihr/en/index.html.

2. Influenza Pandemics of the 20th Century

3. 1918 Influenza: the Mother of All Pandemics

4. Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

5. Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination

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