Modular Multiantigen T Cell Epitope–Enriched DNA Vaccine Against Human Leishmaniasis-Reference-Cited by-同舟云学术

Modular Multiantigen T Cell Epitope–Enriched DNA Vaccine Against Human Leishmaniasis

Published:2014-04-30 Issue:234 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Das Shantanabha¹,Freier Anja²,Boussoffara Thouraya³,Das Sushmita⁴,Oswald Detlef⁵,Losch Florian O.²,Selka Melanie²,Sacerdoti-Sierra Nina⁶,Schönian Gabriele²,Wiesmüller Karl-Heinz⁷,Seifert Karin⁸,Schroff Matthias⁵,Juhls Christiane⁵,Jaffe Charles L.⁶,Roy Syamal¹,Das Pradeep⁴,Louzir Hechmi³,Croft Simon L.⁸,Modabber Farrokh⁹,Walden Peter²

Affiliation:

1. Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology (Council of Scientific and Industrial Research), 4 Raja S.C. Mullick Road, Kolkata 700032, India.

2. Charité–Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

3. Laboratory of Transmission, Control and Immunobiology of Infections, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis Belvédère, Tunisia.

4. Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agam Kuan, Patna 800 007, India.

5. MOLOGEN AG, Fabeckstr. 30, 14195 Berlin, Germany.

6. Department of Microbiology and Molecular Genetics, Hadassah Medical School, Hebrew University, IMRIC, P. O. Box 12272, Jerusalem 91120, Israel.

7. EMC microcollections GmbH, 74072 Tübingen, Germany.

8. Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

9. Drugs for Neglected Diseases Initiative, 15, Chemin Louis-Dunant, 1202 Geneva, Switzerland.

Abstract

A DNA vaccine for the induction of cell-mediated immunity against different types of leishmaniasis was developed and successfully tested in human cell culture systems for immunogenicity and an animal model for prophylaxis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference36 articles.

1. Leishmaniasis Worldwide and Global Estimates of Its Incidence

2. Leishmaniasis: complexity at the host–pathogen interface

3. Leishmaniasis chemotherapy—challenges and opportunities

4. A Review of Preventative Methods against Human Leishmaniasis Infection

5. Vaccines for Canine Leishmaniasis

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