Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes-Reference-Cited by-同舟云学术

Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes

Published:2013-11-13 Issue:211 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Engin Feyza¹,Yermalovich Alena¹,Nguyen Truc¹,Hummasti Sarah¹,Fu Wenxian²,Eizirik Decio L.³,Mathis Diane²⁴,Hotamisligil Gökhan S.¹⁴

Affiliation:

1. Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

2. Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

3. Laboratory of Experimental Medicine, Medical Faculty, Université Libre de Bruxelles, Erasmus Hospital, Campus Erasme, 1070 Brussels, Belgium.

4. The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Abstract

Preservation of insulin-producing pancreatic β cells in type 1 diabetes requires an intact UPR, and treatment with tauroursodeoxycholic acid can restore UPR defects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. Immune cell crosstalk in type 1 diabetes

2. β-Cell death during progression to diabetes

3. Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

4. The role of inflammation in insulitis and β-cell loss in type 1 diabetes

5. The endoplasmic reticulum stress response in immunity and autoimmunity

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