Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease-Reference-Cited by-同舟云学术

Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

Published:2010-07-21 Issue:41 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tye-Din Jason A.¹²³,Stewart Jessica A.¹,Dromey James A.¹,Beissbarth Tim¹,van Heel David A.⁴,Tatham Arthur⁵,Henderson Kate⁶,Mannering Stuart I.¹,Gianfrani Carmen⁷,Jewell Derek P.⁸,Hill Adrian V. S.⁹,McCluskey James¹⁰,Rossjohn Jamie⁶,Anderson Robert P.¹³

Affiliation:

1. Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2. Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.

3. Department of Gastroenterology, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria 3050, Australia.

4. Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.

5. Cardiff School of Health Sciences, University of Wales Institute, Cardiff CF5 2YB, UK.

6. Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.

7. Institute of Food Science, National Research Council, Via Roma 52, 83100 Avellino, Italy.

8. Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

9. Jenner Institute, University of Oxford, Oxford OX3 9DU, UK.

10. Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.

Abstract

Three highly immunogenic peptides from gluten are primarily responsible for celiac disease, suggesting a rational immunotherapeutic approach that could replace the need for strict, lifelong dietary gluten avoidance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

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