Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA-Reference-Cited by-同舟云学术

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

Published:2012-05-30 Issue:136 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Forshew Tim¹,Murtaza Muhammed¹²,Parkinson Christine¹²³,Gale Davina¹,Tsui Dana W. Y.¹,Kaper Fiona⁴,Dawson Sarah-Jane¹²³,Piskorz Anna M.¹²,Jimenez-Linan Mercedes³⁵,Bentley David⁶,Hadfield James¹,May Andrew P.⁴,Caldas Carlos¹²³⁷,Brenton James D.¹²³⁷,Rosenfeld Nitzan¹²

Affiliation:

1. Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

2. Department of Oncology, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK.

3. Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK.

4. Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, CA 94080, USA.

5. Department of Histopathology, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

6. Illumina Cambridge, Chesterford Research Park, Little Chesterford, Cambridge CB10 1XL, UK.

7. Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK.

Abstract

Sizable genomic regions were screened and low-frequency mutations were identified in circulating DNA of cancer patients using tagged-amplicon deep sequencing (TAm-Seq).

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference42 articles.

1. Circulating free DNA in plasma or serum as biomarker of carcinogenesis: Practical aspects and biological significance

2. Detection and quantification of mutations in the plasma of patients with colorectal tumors

3. Circulating mutant DNA to assess tumor dynamics

4. Cell-free nucleic acids as biomarkers in cancer patients

5. Tumor-specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer

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