A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy

Author:

Bruhn Sören1,Fang Yu23,Barrenäs Fredrik1,Gustafsson Mika1,Zhang Huan1,Konstantinell Aelita1,Krönke Andrea4,Sönnichsen Birte4,Bresnick Anne5,Dulyaninova Natalya5,Wang Hui1,Zhao Yelin1,Klingelhöfer Jörg6,Ambartsumian Noona6,Beck Mette K.7,Nestor Colm1,Bona Elsa8,Xiang Zou3,Benson Mikael19

Affiliation:

1. The Center for Individualized Medication, Department of Clinical and Experimental Medicine, Linköping University, 581 85 Linköping, Sweden.

2. Department of Microbiology and Immunology, Affiliated Hospital of Guiyang Medical College, 550004 Guiyang, China.

3. Department of Microbiology and Immunology, Mucosal Immunobiology and Vaccine Research Center, Institute of Biomedicine, University of Gothenburg, 40530 Gothenburg, Sweden.

4. Cenix BioScience GmbH, 01307 Dresden, Germany.

5. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

6. Department of Neuroscience and Pharmacology, University of Copenhagen, 2200 Copenhagen, Denmark.

7. Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark.

8. Department of Paediatrics, Borås Hospital, 50455 Borås, Sweden.

9. Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, 58185 Linköping, Sweden.

Abstract

A module-based strategy identified and validated an important diagnostic and therapeutic candidate gene in allergy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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