Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota-Reference-Cited by-同舟云学术

Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota

Published:2013-02-13 Issue:172 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zheng Xiaojiao¹²,Zhao Aihua¹²,Xie Guoxiang³,Chi Yi²,Zhao Linjing²,Li Houkai³,Wang Congrong¹,Bao Yuqian¹,Jia Weiping¹,Luther Mike⁴,Su Mingming⁴,Nicholson Jeremy K.⁵,Jia Wei¹²³

Affiliation:

1. Center for Translational Medicine, and Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China.

2. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

3. Center for Translational Biomedical Research, University of North Carolina at Greensboro, North Carolina Research Campus, Kannapolis, NC 28081, USA.

4. David H. Murdock Research Institute, North Carolina Research Campus, Kannapolis, NC 28081, USA.

5. Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, UK.

Abstract

Melamine is converted to cyanuric acid by the gut microbe Klebsiella , leading to melamine-cyanurate-urate coprecipitation that is associated with nephrotoxicity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference42 articles.

1. Chinese Probe Unmasks High-Tech Adulteration With Melamine

2. Outbreaks of Renal Failure Associated with Melamine and Cyanuric Acid in Dogs and Cats in 2004 and 2007

3. Urinary tract abnormalities in Chinese rural children who consumed melamine-contaminated dairy products: a population-based screening and follow-up study

4. World Health Organization Melamine and Cyanuric Acid: Toxicity Preliminary Risk Assessment and Guidance on Levels in Food (World Health Organization Geneva 2008).

5. Imipenem/Cilastatin

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