Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody-Reference-Cited by-同舟云学术

Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody

Author:

Iwama Shintaro¹²,De Remigis Alessandra¹,Callahan Margaret K.³⁴,Slovin Susan F.³⁴,Wolchok Jedd D.³⁴⁵,Caturegli Patrizio¹⁶

Affiliation:

1. Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.

2. Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

3. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

4. Weill Cornell Medical College, New York, NY 10065, USA.

5. Ludwing Institute for Cancer Research, New York, NY 10065, USA.

6. Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Abstract

CTLA-4 blocking antibody induces secondary hypophysitis by binding to CTLA-4 antigen and initiating a type II hypersensitivity reaction.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

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