Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of T H 17 to Regulatory T Cells in HIV Disease-Reference-Cited by-同舟云学术

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of T H 17 to Regulatory T Cells in HIV Disease

Published:2010-05-19 Issue:32 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Favre David¹,Mold Jeff¹,Hunt Peter W.²,Kanwar Bittoo¹³,Loke P’ng¹,Seu Lillian¹,Barbour Jason D.²,Lowe Margaret M.¹,Jayawardene Anura⁴,Aweeka Francesca⁴,Huang Yong⁵,Douek Daniel C.⁶,Brenchley Jason M.⁷,Martin Jeffrey N.⁸,Hecht Frederick M.²,Deeks Steven G.²,McCune Joseph M.¹

Affiliation:

1. Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA.

2. HIV/AIDS Program, Department of Medicine, University of California, San Francisco, CA 94110, USA.

3. Division of Gastroenterology, Department of Pediatrics, University of California, San Francisco, CA 94110, USA.

4. Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, CA 94143, USA.

5. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.

6. Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

7. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

8. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.

Abstract

Patients with AIDS have fewer immune cells to defend against microbial invasion through the gut, a critical loss that may be caused by a tryptophan metabolite produced by other immune cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

1. Emerging Concepts in the Immunopathogenesis of AIDS

2. The dynamics of CD4+ T-cell depletion in HIV disease

3. Cytokines and cytokine therapies in HIV infection.;Valdez H.;AIDS Clin. Rev.,1997

4. Tryptophan depletion and HIV Tryptophan depletion and HIV infection: a metabolic link to pathogenesis

5. Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

Cited by 457 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immune Characteristics and Immunotherapy of HIV-Associated Lymphoma;Current Issues in Molecular Biology;2024-09-10

2. Galectin 9 Levels as a Potential Predictor of Intact HIV Reservoir Decay;The Journal of Infectious Diseases;2024-08-28

3. The aryl hydrocarbon receptor pathway: a linking bridge between the gut microbiome and neurodegenerative diseases;Frontiers in Cellular Neuroscience;2024-08-08

4. Prepandemic Metabolic Correlates of Coronavirus Disease 2019 (COVID-19) Severity and Long COVID Incidence in People Living With HIV;The Journal of Infectious Diseases;2024-07-16

5. The Complex Dysregulations of CD4 T Cell Subtypes in HIV Infection;International Journal of Molecular Sciences;2024-07-09