First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip-Reference-Cited by-同舟云学术

First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip

Published:2012-02-22 Issue:122 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Farra Robert¹,Sheppard Norman F.¹,McCabe Laura¹,Neer Robert M.²,Anderson James M.³,Santini John T.⁴,Cima Michael J.⁵,Langer Robert⁶

Affiliation:

1. MicroCHIPS, Inc., Waltham, MA 02451, USA.

2. Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

3. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

4. On Demand Therapeutics Inc., Tyngsboro, MA 01879, USA.

5. Department of Materials Science and Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Implanted in humans, a wirelessly controlled, microchip-based drug delivery device demonstrates pharmacokinetic profiles of an anti-osteoporosis drug that are similar to subcutaneous injections.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference27 articles.

1. A Polymer-Based, Paclitaxel-Eluting Stent in Patients with Coronary Artery Disease

2. A controlled-release microchip

3. Multi-pulse drug delivery from a resorbable polymeric microchip device

4. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device

5. J. R. Coppeta K. Shelton N. F. Sheppard Jr. D. Snell C. M. B. Santini Compression and cold weld sealing methods and devices U.S. Patent 2006/0115323 A1 (2006).

Cited by 360 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Next-generation chemotherapy treatments based on black hole algorithms: From cancer remission to chronic disease management;Computers in Biology and Medicine;2024-09

2. Advanced material technologies for space and terrestrial medicine;Nature Reviews Materials;2024-06-03

3. Adhesive anti-fibrotic interfaces on diverse organs;Nature;2024-05-22

4. Design and preparation of an electromechanical implant prototype for an on-demand drug delivery;Journal of the Mechanical Behavior of Biomedical Materials;2024-03

5. Programmable Delivery of Fluoxetine via Wearable Bioelectronics for Wound Healing In Vivo;Advanced Materials Technologies;2024-02-05