A Neutralizing Human Monoclonal Antibody Protects African Green Monkeys from Hendra Virus Challenge

Author:

Bossart Katharine N.12,Geisbert Thomas W.34,Feldmann Heinz56,Zhu Zhongyu78,Feldmann Friederike9,Geisbert Joan B.34,Yan Lianying10,Feng Yan-Ru10,Brining Doug11,Scott Dana11,Wang Yanping78,Dimitrov Antony S.12,Callison Julie5,Chan Yee-Peng10,Hickey Andrew C.12,Dimitrov Dimiter S.7,Broder Christopher C.10,Rockx Barry5

Affiliation:

1. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

2. National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, MA 02118, USA.

3. Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA.

4. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.

5. Laboratory of Virology, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.

6. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

7. Protein Interactions Group, Center for Cancer Research Nanobiology Program, National Cancer Institute–Frederick, National Institutes of Health, Frederick, MD 21702, USA.

8. Behavioral Research Program, Science Applications International Corporation–Frederick Inc., Frederick, MD 21702, USA.

9. Offices of Operations and Management, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.

10. Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.

11. Rocky Mountain Veterinary Branch, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.

12. Profectus BioSciences Inc., Baltimore, MD 21224, USA.

Abstract

A neutralizing human monoclonal antibody can fully protect nonhuman primates from disease after a lethal Hendra virus challenge.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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