Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis-Reference-Cited by-同舟云学术

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

Published:2014-08-06 Issue:248 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Palanichamy Arumugam¹,Apeltsin Leonard¹,Kuo Tracy C.²,Sirota Marina²,Wang Shengzhi¹,Pitts Steven J.²,Sundar Purnima D.²,Telman Dilduz²,Zhao Lora Z.²,Derstine Mia¹,Abounasr Aya¹,Hauser Stephen L.¹,von Büdingen H.-Christian¹

Affiliation:

1. Department of Neurology, University of California, San Francisco, San Francisco, CA 94148, USA.

2. Rinat-Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA 94080, USA.

Abstract

Ig class-switched B cells connect the periphery and CNS and support peripheral antigen-driven B cell activation in CNS autoimmunity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

1. Rituximab in relapsing-remitting multiple sclerosis: A 72-week, open-label, phase I trial

2. B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

3. Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

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