Anthrax Vaccine–Induced Antibodies Provide Cross-Species Prediction of Survival to Aerosol Challenge

Author:

Fay Michael P.1,Follmann Dean A.1,Lynn Freyja2,Schiffer Jarad M.3,Stark Gregory V.4,Kohberger Robert5,Quinn Conrad P.3,Nuzum Edwin O.2

Affiliation:

1. Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, Bethesda, MD 20892–7630, USA.

2. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, 6610 Rockledge Drive, Bethesda, MD 20892–6604, USA.

3. Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.

4. Battelle, 505 King Avenue, Columbus, OH 43201, USA.

5. Blair & Co., Greenwich, CT 06830, USA.

Abstract

Lethal toxin–neutralizing activity in serum after vaccination can provide cross-species predictions of survival against inhalation anthrax.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

1. Food and Drug Administration Subpart H—Approval of Biological Products When Human Efficacy Studies Are Not Ethical or Feasible (Food and Drug Administration Silver Spring MD 2009).

2. The FDA animal efficacy rule and biodefense

3. Vaccines: Correlates of Vaccine‐Induced Immunity

4. Use of statistical models for evaluating antibody response as a correlate of protection against varicella

5. Prediction of pertussis vaccine efficacy using a correlates of protection model

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