TRANSLOCATION Project: How to Get Good Drugs into Bad Bugs
Author:
Affiliation:
1. Robert A. Stavenger is Team Leader in the Antibacterial Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.
2. Mathias Winterhalter is Professor of Biophysics, Jacobs University Bremen, 28759 Bremen, Germany.
Abstract
Publisher
American Association for the Advancement of Science (AAAS)
Subject
General Medicine
Reference8 articles.
1. Drugs for bad bugs: confronting the challenges of antibacterial discovery
2. Antimicrobial therapeutics reviews: The bacterial cell wall as an antimicrobial target. Ann. N.Y. Acad. Sci . vol. 1277 K. Bush Ed. (Wiley-Blackwell New York 2013).
3. The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
4. Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution
5. Antibiotic Permeation across the OmpF Channel: Modulation of the Affinity Site in the Presence of Magnesium
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