AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T H 1 response with a diverse TCR repertoire

Author:

Swanson Phillip A.1ORCID,Padilla Marcelino1,Hoyland Wesley1,McGlinchey Kelly2ORCID,Fields Paul A.3ORCID,Bibi Sagida4ORCID,Faust Saul N.5ORCID,McDermott Adrian B.1ORCID,Lambe Teresa67ORCID,Pollard Andrew J.4ORCID,Durham Nicholas M.8ORCID,Kelly Elizabeth J.9ORCID,

Affiliation:

1. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Discovery, Research and Early Development, Oncology R&D, AstraZeneca, Gaithersburg, MD 20878, USA.

3. Adaptive Biotechnologies, Seattle, WA 98102, USA.

4. Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and NIHR Oxford Biomedical Research Centre, Oxford OX4 6PG, UK.

5. NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, and Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO16 6YD, UK.

6. The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK.

7. Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK.

8. Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD 20878, USA.

9. Translational Medicine, Microbial Sciences, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.

Abstract

Polyfunctional CD4 + and CD8 + T cell responses are elicited against the SARS-CoV-2 spike protein after two doses of the AZD1222 COVID-19 vaccine.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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