GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults

Author:

Lanini Simone1ORCID,Capone Stefania2ORCID,Antinori Andrea1,Milleri Stefano3,Nicastri Emanuele1ORCID,Camerini Roberto2,Agrati Chiara1,Castilletti Concetta1ORCID,Mori Federica2,Sacchi Alessandra1ORCID,Matusali Giulia1,Gagliardini Roberta1ORCID,Ammendola Virginia2,Cimini Eleonora1ORCID,Grazioli Fabiana2ORCID,Scorzolini Laura1,Napolitano Federico2,Plazzi Maria M.1ORCID,Soriani Marco2ORCID,De Luca Aldo1ORCID,Battella Simone2ORCID,Sommella Andrea2ORCID,Contino Alessandra M.2ORCID,Barra Federica2ORCID,Gentile Michela2,Raggioli Angelo2ORCID,Shi Yufang45ORCID,Girardi Enrico1ORCID,Maeurer Markus67ORCID,Capobianchi Maria R.18,Vaia Francesco1,Piacentini Mauro9ORCID,Kroemer Guido10111213ORCID,Vitelli Alessandra2,Colloca Stefano2,Folgori Antonella2ORCID,Ippolito Giuseppe1ORCID

Affiliation:

1. Istituto Nazionale per Le Malattie Infettive Lazzaro Spallanzani IRCCS, 00149 Rome, Italy.

2. ReiThera Srl, 00128 Rome, Italy.

3. Centro Ricerche Cliniche di Verona Srl, 37134 Verona, Italy.

4. First Affiliated Hospital of Soochow University, Suzhou 215008, Jiangsu, China.

5. Shanghai Institute of Nutrition and Health and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200061 Shanghai, China.

6. Division of Immunotherapy, ImmunoSurgery, Champalimaud Foundation, 1400-038 Lisboa, Portugal.

7. I Medical Clinic, University of Mainz, 55122 Mainz, Germany.

8. Saint Camillus International University of Health Sciences, 00131 Rome, Italy.

9. Department of Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy.

10. Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, 75006 Paris, France.

11. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.

12. Pôle de Biologie, Hôpital Européen Georges Pompidou, 75015 Paris, France.

13. Department of Women’s and Children’s Health, Karolinska University Hospital, 17164 Stockholm, Sweden.

Abstract

GRAd-COV2, a candidate vaccine for COVID-19 based on a gorilla adenovirus, is safe and immunogenic in younger and older adults.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

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