Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington’s disease

Author:

Byrne Lauren M.1ORCID,Rodrigues Filipe B.1ORCID,Johnson Eileanor B.1ORCID,Wijeratne Peter A.2,De Vita Enrico34ORCID,Alexander Daniel C.25,Palermo Giuseppe6,Czech Christian6ORCID,Schobel Scott6,Scahill Rachael I.1,Heslegrave Amanda7,Zetterberg Henrik78910,Wild Edward J.1ORCID

Affiliation:

1. Huntington’s Disease Centre, University College London (UCL) Institute of Neurology, London WC1N 3BG, UK.

2. Centre for Medical Image Computing, Department of Computer Science, UCL, London WC1E 6EA, UK.

3. Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.

4. Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UK.

5. Clinical Imaging Research Centre, National University of Singapore, Singapore 117599, Singapore.

6. Neuroscience, Ophthalmology, and Rare Diseases, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffman–La Roche Ltd., 4070 Basel, Switzerland.

7. Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

8. UK Dementia Research Institute at UCL, London WC1E 6BT, UK.

9. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, 405 30 Gothenburg, Sweden.

10. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, 413 45 Gothenburg, Sweden.

Abstract

Mutant huntingtin and neurofilament in biofluids may have prognostic potential in Huntington’s disease.

Funder

Wellcome Trust

CHDI Foundation

Horizon 2020 Framework Programme

Medical Research Council

Engineering and Physical Sciences Research Council

Wellcome/EPSRC Centre for Medical Engineering

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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