Comment on “Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin”-Reference-Cited by-同舟云学术

Comment on “Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin”

Published:2017-05-24 Issue:391 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Winter Stefan¹,Fisel Pascale¹,Büttner Florian¹,Nies Anne T.¹^ORCID,Stenzl Arnulf²³,Bedke Jens²³,Schwab Matthias¹²⁴⁵^ORCID,Schaeffeler Elke¹

Affiliation:

1. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Auerbachstr.112, 70376 Stuttgart, Germany.

2. German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany.

3. Department of Urology, University Hospital Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.

4. Department of Clinical Pharmacology, University Hospital Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany.

5. Department of Pharmacy and Biochemistry, University of Tuebingen, 72076 Tuebingen, Germany.

Abstract

Although the combination of decitabine and platinum drugs may be promising for therapy of renal cell carcinoma, the role of OCT2 needs further investigations.

Funder

Robert Bosch Stiftung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference10 articles.

1. Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin

2. Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

3. Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)

4. Renal Transporters in Drug Development

5. Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity

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