Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion-Reference-Cited by-同舟云学术

Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

Published:2017-04-26 Issue:387 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

He Shenghui¹²^ORCID,Roberts Patrick J.³,Sorrentino Jessica A.³^ORCID,Bisi John E.³^ORCID,Storrie-White Hannah³,Tiessen Renger G.⁴^ORCID,Makhuli Karenann M.³^ORCID,Wargin William A.⁵^ORCID,Tadema Henko⁴^ORCID,van Hoogdalem Ewoud-Jan⁴,Strum Jay C.³,Malik Rajesh³^ORCID,Sharpless Norman E.¹²^ORCID

Affiliation:

1. Departments of Genetics and Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599–7295, USA.

2. Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599–7295, USA.

3. G1 Therapeutics Inc., Research Triangle Park, NC 27709, USA.

4. PRA Health Sciences, P.O. Box 200, 9470 AE Zuidlaren, Netherlands.

5. Nuventra Pharma Sciences, Research Triangle Park, NC 27713, USA.

Abstract

The concomitant use of CDK4/6 inhibitors with cytotoxic agents may prevent chemotherapy-induced bone marrow exhaustion in cancer patients.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)