Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells-Reference-Cited by-同舟云学术

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

Published:2017-01-25 Issue:374 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Qasim Waseem¹²,Zhan Hong¹,Samarasinghe Sujith²,Adams Stuart²,Amrolia Persis¹²,Stafford Sian¹,Butler Katie¹,Rivat Christine¹,Wright Gary²,Somana Kathy²,Ghorashian Sara¹,Pinner Danielle²,Ahsan Gul²,Gilmour Kimberly²,Lucchini Giovanna²,Inglott Sarah²,Mifsud William²,Chiesa Robert²,Peggs Karl S.³,Chan Lucas⁴,Farzaneh Farzin⁴,Thrasher Adrian J.¹,Vora Ajay⁵,Pule Martin³,Veys Paul¹

Affiliation:

1. Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.

2. Great Ormond Street Hospital National Health Service Trust, London WC1N 1LE, UK.

3. Cancer Institute, University College London, London WC1E 6DD, UK.

4. Division of Cancer Studies, Department of Haematological Medicine, King’s College London, London SE5 9NU, UK.

5. Sheffield Children’s Hospital, Sheffield S10 2TH, UK.

Abstract

Universal gene-edited CAR19 T cells eliminate infant leukemia.

Funder

European Union FP7

NIHR

Wellcome Trust