Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

Author:

Karuppagounder Saravanan S.12,Alim Ishraq12,Khim Soah J.12,Bourassa Megan W.12,Sleiman Sama F.12,John Roseleen3,Thinnes Cyrille C.4,Yeh Tzu-Lan4,Demetriades Marina4,Neitemeier Sandra5,Cruz Dana6,Gazaryan Irina12,Killilea David W.7,Morgenstern Lewis8,Xi Guohua9,Keep Richard F.9,Schallert Timothy10,Tappero Ryan V.11,Zhong Jian12,Cho Sunghee12,Maxfield Frederick R.6,Holman Theodore R.12,Culmsee Carsten5,Fong Guo-Hua13,Su Yijing14,Ming Guo-li14,Song Hongjun14,Cave John W.12,Schofield Christopher J.4,Colbourne Frederick3,Coppola Giovanni15,Ratan Rajiv R.12

Affiliation:

1. Sperling Center for Hemorrhagic Stroke Recovery, Burke Medical Research Institute, White Plains, NY 10605, USA.

2. Feil Family Brain and Mind Research Institute, Weill Medical College of Cornell University, New York, NY 10065, USA.

3. Department of Psychology, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.

4. Department of Chemistry, University of Oxford, OX1 3TA Oxford, UK.

5. Institut fuer Pharmakologie and Klinische Pharmazie, Phillips-Universitaet Marburg, D 35032 Marburg, Germany.

6. Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10065, USA.

7. Children’s Hospital of Oakland, Oakland, CA 94609, USA.

8. Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.

9. Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.

10. Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA.

11. Photon Sciences Directorate, Brookhaven National Laboratory, Upton, NY 11973, USA.

12. Chemistry and Biochemistry, Department, University of California at Santa Cruz, Santa Cruz, CA 95064, USA.

13. Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.

14. Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

15. Department of Psychiatry, University of California at Los Angeles, CA 90095, USA.

Abstract

Blocking oxygen-sensing prolyl hydroxylases in the rodent CNS enhances functional recovery after brain hemorrhage.

Funder

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Burke Foundation

Sperling Center for Hemorrhagic Stroke Recovery

New York State Department of Health Center for Research Excellence in Spinal Cord Injury

NIH

National Institute of Neurological Disorders and Stroke

Welcome Trust

British Heart Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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