Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair-Reference-Cited by-同舟云学术

Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair

Published:2015-11-04 Issue:312 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tarish Firas L.¹²,Schultz Niklas¹,Tanoglidi Anna³,Hamberg Hans⁴,Letocha Henry⁵,Karaszi Katalin⁶,Hamdy Freddie C.⁶,Granfors Torvald²,Helleday Thomas¹

Affiliation:

1. Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden.

2. Department of Urology, Central Hospital, 721 89 Västerås, Sweden.

3. Department of Clinical Pathology, Uppsala University Hospital, 751 85 Uppsala, Sweden.

4. Department of Pathology, Central Hospital, 721 89 Västerås, Sweden.

5. Department of Oncology, Central Hospital, 721 89 Västerås, Sweden.

6. Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, OX3 9DU Oxford, UK.

Abstract

Chemical castration decreases Ku70 expression impairing nonhomologous end joining DNA repair and improving the radiotherapy response of prostate cancer patients.

Funder

Torsten and Ragnar Soderberg Foundation

AstraZeneca

Prostate Cancer UK

European Research Council

AFA insurance

Swedish Cancer Society

Swedish Research Council

Centre for Clinical Research

Swedish Pain Relief Foundation

Vastmanland Research Foundation for Cancer in Vasteras

Henning and Ida Persson Research Foundation