The 20 S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection-Reference-Cited by-同舟云学术

The 20 S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

Published:2015-12-16 Issue:318 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Dieudé Mélanie¹²,Bell Christina²³,Turgeon Julie¹²,Beillevaire Deborah¹²,Pomerleau Luc¹²,Yang Bing¹²,Hamelin Katia¹²,Qi Shijie¹²,Pallet Nicolas¹,Béland Chanel¹,Dhahri Wahiba¹,Cailhier Jean-François¹²,Rousseau Matthieu²⁴,Duchez Anne-Claire²⁴,Lévesque Tania²⁴,Lau Arthur²⁵,Rondeau Christiane⁶,Gingras Diane⁶,Muruve Danie²⁵,Rivard Alain¹,Cardinal Héloise¹²,Perreault Claude²³,Desjardins Michel⁶,Boilard Éric²⁴,Thibault Pierre²³,Hébert Marie-Josée¹²

Affiliation:

1. Research Centre, Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec G1V 4G2, Canada.

2. Canadian National Transplantation Research Program, Edmonton, Alberta T6G 2E1, Canada.

3. Institute for Research in Immunology and Cancer (IRIC), Montréal, Québec H3T 1JA, Canada.

4. Centre de Recherche du CHU de Québec, Québec, Québec G1V 4G2, Canada.

5. University of Calgary, Calgary, Alberta T2N 1N4, Canada.

6. Université de Montréal, Montréal, Québec H3T 1J4, Canada.

Abstract

Exosome-like vesicles containing an active 20 S proteasome core contribute to autoimmunity and vascular allograft inflammation.

Funder

Canadian Cancer Society Research Institute (CCSRI)

Canadian Institutes of Health Research (CIHR)